RNAi Controls
Medchemexpress LLC Robo1 recombinant protein (rat, HEK293, C-terminal His tag) | 10UG
Recombinant rat ROBO1 receptor protein produced in HEK293 cells with a C-terminal His tag. The product is glycosylated and purified to high quality, making it suitable for binding, structural, and biochemical studies. Supplied as 10 μg with an approximate molecular weight of 70-95 kDa and >95% purity. Store at -20°C and aliquot for extended storage; after reconstitution it is stable at 4°C for short-term use.
Genscript Corporation SIRP Fc Chimera Human
Signal regulatory protein alpha (SIRP designated CD172a) is also known as CD172 antigen-like family member A (CD172a) also called SHPS-1 (SHP substrate 1) and previously MyD-1 (Myeloid/Dendritic-1) which is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily SIRP is Ubiquitous and highly expressed in brain SIRPA/CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6 PTPN11 and other binding partners from the cytosol to the plasma membrane SIRPA/SHPS-1 supports adhesion of cerebellar neurons neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function by similarity SIRP recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production
Genscript Corporation SLAMF7/CRACC/CD319 hFc Chimera
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Genscript Corporation CD99/MIC2 hFc Chimera Human
CD99 is a cell surface protein with unique features and only partly defined mechanisms of action This molecule is involved in crucial biological processes including cell adhesion migration death differentiation and diapedesis and it influences processes associated with inflammation immune responses and cancer CD99 is frequently overexpressed in many types of tumors particularly pediatric tumors including Ewing sarcoma and specific subtypes of leukemia
Genscript Corporation PD-L1 Fc Chimera Human
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy tissue allografts autoimmune disease and other disease states such as hepatitis Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8 T cell The formation of PD-1 receptor / PD-L1 or B7 1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8 T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2 PD-L
Genscript Corporation IL-17R alpha/CD217 hFc Chimera
Interleukin 17 (also known as CTLA 8) is a T cell expressed pleotropic cytokine IL 17 binds to IL 17 receptor (IL 17 R) which shares no homology with any known family of receptors While the expression of IL 17 is restricted to activated T cells the IL 17 R mRNA exhibits a broad tissue distribution and has been detected in virtually all cells and tissues tested The human IL 17 R gene was localized to chromosome 22
Genscript Corporation CD52 mFc Chimera Human
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation GLP-1R mFc Chimera Human
The GLP1R a GPCR is found on pancreatic beta cells and brain neurons It regulates blood sugar by enhancing insulin secretion In humans it is encoded by the gene GLP1R on chromosome 6 GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1 The TMD domain contains polar residues that regulate biased signaling while the transmembrane helical boundaries and extracellular surface trigger biased agonism
Genscript Corporation CD160 Fc Chimera Human
CD160 is a glycosylphosphatidylinositol-anchored Ig domain protein that is expressed on almost all intestinal intraepithelial lymphocytes (IELs) T (gamma delta T) cells NK (natural killer) cells and a minor subset of CD4 and CD8 T cells In terms of function work has centered on the role of CD160 in enhancing NK or CD8 T cell activation Such effects have been attributed to the ability of CD160 to bind classical and nonclassical MHC class I molecules although with apparent low affinity requiring clustering of MHC class I molecules or overexpression of CD160 or MHC class I for detection of the interaction
Genscript Corporation CD3ECD3G hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 gamma chain also known as CD3E CD3G are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD52 hFc Chimera Mouse
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation Siglec-15/CD33L3 hFc Chimera
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains a 21 aa transmembrane segment and a 44 aa cytoplasmic domain Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates
Genscript Corporation CD161 hFc Chimera Human
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment
Genscript Corporation CD27/TNFRSF7 hFc Chimera Huma
CD27 also known as TNFRSF7 is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily It functions as a co stimulatory molecule that supports lymphocyte activation and survival It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis
Genscript Corporation CD164 hFc Chimera Human
CD164 was found to play a role in many malignant diseases CD164 was associated with clinical and pathological features of patients High level of CD164 was related to the distant metastasis and vascular invasion of bladder cancer patients CD164 was associated with the poor clinical outcomes of BC patients Silencing of CD164 could inhibit the progression of tumors in vivo and in vitro which may become an effective target in the treatment of bladder cancer